Publications (for a fully updated list, visit PubMed)

Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen D-D, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun J-P, Xie X, Yu X, Zhang Y. Structural basis of GPBAR activation and bile acid recognition. Nature. 2020 Jul 22; PMID: 32698187

 

Payne KK, Mine JA, Biswas S, Chaurio RA, Perales-Puchalt A, Anadon CM, Costich TL, Harro CM, Walrath J, Ming Q, Tcyganov E, Buras AL, Rigolizzo KE, Mandal G, Lajoie J, Ophir M, Tchou J, Marchion D, Luca VC, Bobrowicz P, McLaughlin B, Eskiocak U, Schmidt M, Cubillos-Ruiz JR, Rodriguez PC, Gabrilovich DI, Conejo-Garcia JR. BTN3A1 governs antitumor responses by coordinating αβ and γδ T cells. Science. 2020 21;369(6506):942–949. PMID: 32820120

Luca VC*, Miao Y*, Li X, Hollander MJ, Kuo CJ, Garcia KC. Surrogate R-spondins for tissue-specific potentiation of Wnt Signaling. PLoS ONE. 2020 Jan 8 [cited 2020 Jun 2];15(1). PMCID: PMC6949110

*These authors contributed equally, VCL and KCG are co-corresponding authors

Ming Q, Gonzalez-Perez D, Luca VC. Molecular engineering strategies for visualizing low-affinity protein complexes. Exp Biol Med. 2019 Jun 11;1535370219855401.

Schneider M, Kumar V, Nordstrøm LU, Feng L, Takeuchi H, Hao H, Luca VC, Garcia KC, Stanley P, Wu P, Haltiwanger RS. Inhibition of Delta-induced Notch signaling using fucose analogs. Nat Chem Biol. 2017 Nov 27; PMID: 29176671

Lim JS, Ibaseta A, Fischer MM, Cancilla B, O’Young G, Cristea S, Luca VC, Yang D, Jahchan NS, Hamard C, Antoine M, Wislez M, Kong C, Cain J, Liu Y-W, Kapoun AM, Garcia KC, Hoey T, Murriel CL, Sage J. Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer. Nature. 2017 May 18;545(7654):360–364.

Yan KS, Janda CY, Chang J, Zheng GXY, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC, Kuo CJ. Non-equivalence of Wnt and R-spondin ligands during Lgr5(+) intestinal stem-cell self-renewal. Nature. 2017 May 3; PMID: 28467820

Luca VC, Kim BC, Ge C, Kakuda S, Wu D, Roein-Peikar M, Haltiwanger RS, Zhu C, Ha T, Garcia KC. Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity. Science. 2017 Mar 2;eaaf9739. PMID: 28254785

Zuiani A, Chen K, Schwarz MC, White JP, Luca VC, Fremont DH, Wang D, Evans MJ, Diamond MS. A Library of Infectious Hepatitis C Viruses with Engineered Mutations in the E2 Gene Reveals Growth-Adaptive Mutations That Modulate Interactions with Scavenger Receptor Class B Type I. J Virol. 2016 Dec 1;90(23):10499–10512. PMCID: PMC5110168

Spangler JB, Tomala J, Luca VC, Jude KM, Dong S, Ring AM, Votavova P, Pepper M, Kovar M, Garcia KC. Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms. Immunity. 2015 May 19;42(5):815–825. PMCID: PMC4439582

Luca VC, Jude KM, Pierce NW, Nachury MV, Fischer S, Garcia KC. Structural biology. Structural basis for Notch1 engagement of Delta-like 4. Science. 2015 Feb 20;347(6224):847–853. PMID: 25700513

Luca VC, Nelson CA, Fremont DH. Structure of the St. Louis encephalitis virus postfusion envelope trimer. J Virol. 2012 Oct 31; PMID: 23115296

Luca VC, AbiMansour J, Nelson CA, Fremont DH. Crystal Structure of the Japanese Encephalitis Virus Envelope Protein. Spotlight Article. J Virol. 2012 Feb 15;86(4):2337–2346.

Sabo MC, Luca VC, Ray SC, Bukh J, Fremont DH, Diamond MS. Hepatitis C virus epitope exposure and neutralization by antibodies is affected by time and temperature. Virology. 2012 Jan 20;422(2):174–184. PMID: 22078164

Sabo MC, Luca VC, Prentoe J, Hopcraft SE, Blight KJ, Yi M, Lemon SM, Ball JK, Bukh J, Evans MJ, Fremont DH, Diamond MS. Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step. J Virol. 2011 Jul;85(14):7005–7019. PMID: 21543495

Reviews & Media

Blacklow SC. News and Views: Notch catches a Jagged edge. Nat Chem Biol. 2017 May 17;(13):570–571.

Ray BL. This Week in Science: Tugging on Notch receptor tunes signaling. Science. 2017 Mar 24;355(6331):1277.

Strzyz P. Cell signalling: Notch under tension. Nat Rev Mol Cell Biol. 2017 Apr;18(4):213–213.

Vinson V. This Week in Science: An Interaction that guides cell fate. Science. 2015 Feb 20;347(6224):836.

The Luca Lab

Department of Drug Discovery

Stabile Research Building (3rd floor)

12902 Magnolia Dr, Tampa, FL 33612

Contact

Vince.Luca@moffitt.org

Admin: 813-745-1425

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